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Can you die from xeroderma pigmentosum?

Can you die from xeroderma pigmentosum?

Normal cells are usually able to fix DNA damage before it causes problems. However, in people with xeroderma pigmentosum, DNA damage is not repaired normally. As more abnormalities form in DNA, cells malfunction and eventually become cancerous or die.

How do you get XP disease?

What causes xeroderma pigmentosum? XP is an inherited disorder. Each subtype is caused by a mutation in a different gene. Every type of XP is marked by the gene’s inability to repair, or replicate, DNA that has been damaged by UV light.

What are the symptoms of XP?


  • Sunburn that does not heal after just a little bit of sun exposure.
  • Blistering after just a little bit of sun exposure.
  • Spider-like blood vessels under the skin.
  • Patches of discolored skin that get worse, resembling severe aging.
  • Crusting of the skin.
  • Scaling of the skin.
  • Oozing raw skin surface.

Is there a disease called XP?

People who have an extreme sensitivity to sunlight are born with a rare disease known as xeroderma pigmentosum (XP). They must take extreme measures to protect their skin from ultraviolet (UV) light. Anything that emits UV light, including the sun and some lightbulbs, can damage their skin.

Can xeroderma pigmentosum be prevented?

There is no cure for xeroderma pigmentosum. Gene therapy for xeroderma pigmentosum is still in a hypothetical and investigational stage. Family members and known carriers should undergo genetic counselling and avoid consanguineous marriage.

How long can you live with XP?

Prognosis. The average life expectancy of an individual with any type of XP and no neurological symptoms is approximately 37 years, and 29 years if neurological symptoms are present.

Are you born with XP?

XP is a genetic condition that people are born with. This means that the risk of XP can be passed from generation to generation in a family. Mutations (alterations) in at least 8 different genes are known to play a role in XP.

When do you have a rare disease called XP?

When you have a rare disease called XP, you must take extreme precautions to protect your skin from the sun. People who have XP need this extreme protection because their bodies cannot protect them from UV light.

How does XP increase the risk of skin cancer?

This happens because they inherit genes that prevent their bodies from repairing damage caused by UV light. Because the body cannot protect itself from UV light, a person’s risk of getting skin cancer skyrockets. It’s estimated that XP can raise the risk of getting skin cancer 10,000-fold.

How does the autosomal recessive disorder XP affect the body?

XP affects the mechanism that repairs UV damage in skin cell DNA. Those affected with the autosomal recessive disorder XP are extremely sensitive to UV light produced by the sun and develop pigmented spots, tumors, and skin cancer with minimal exposure.

Is it painful for a person to die from COPD?

However, because pain is subjective, it is difficult to generalize as to the amount of pain experienced by any one individual, explains an article on When a patient is dying from COPD, doctors prescribe medicines to alleviate the his symptoms to the greatest extent possible.