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What is the role of the choroid plexus in the blood-brain barrier?

What is the role of the choroid plexus in the blood-brain barrier?

One of the primary functions is to produce cerebrospinal fluid (CSF) via the ependymal cells that line the ventricles of the brain. Secondly, the choroid plexus serves as a barrier in the brain separating the blood from the CSF, known as the blood-CSF barrier.

What is the blood-CSF barrier formed by?

The BBB and the blood-cerebrospinal fluid barrier (BCSFB) are formed by brain endothelial cells (BECs) and choroid plexus (CP) epithelial cells, respectively. The BBB and the BCSFB are not only anatomical barriers, but also dynamic tissues that express multiple transporters, receptors and enzymes.

What is the function of the choroid plexus in the brain?

The choroid plexus epithelium has functions as a barrier at the interface between the blood and cerebrospinal fluid (CSF) highly differentiated. The choroid plexus is located within cerebral ventricles and form the barrier called Blood-CDF-barrier (BCSFB).

How does choroid plexus produce CSF?

The choroid plexus folds into many villi around each capillary, creating frond-like processes that project into the ventricles. The villi, along with a brush border of microvilli, greatly increase the surface area of the choroid plexus. CSF is formed as plasma is filtered from the blood through the epithelial cells.

What is the function of choroid?

The choroid supplies the outer retina with nutrients, and maintains the temperature and volume of the eye. The choroidal circulation, which accounts for 85% of the total blood flow in the eye, is a high-flow system with relatively low oxygen content.

Is the choroid plexus part of the blood brain barrier?

The choroid plexuses are the main structures that comprise the blood-CSF barrier, the other contributors being the arachnoid and arachnoid villi on the outer surface of the brain (Wright, 1978; and for review see Davson and Segal, 1996).

Is CSF similar to blood?

CSF is derived from blood plasma and is largely similar to it, except that CSF is nearly protein-free compared with plasma and has some different electrolyte levels. Due to the way it is produced, CSF has a higher chloride level than plasma, and an equivalent sodium level.

Is the choroid plexus part of the blood-brain barrier?

Why is the choroid plexus important?

The choroid plexus (ChP) is a secretory tissue found in each of the brain ventricles, the main function of which is to produce cerebrospinal fluid (CSF).

What do you mean by choroid plexus?

Listen to pronunciation. (KOR-oyd PLEK-sus) A network of blood vessels and cells in the ventricles (fluid-filled spaces) of the brain. The blood vessels are covered by a thin layer of cells that make cerebrospinal fluid.