Which is an example of an idiosyncratic reaction?
Idiosyncratic reactions are unpredictable and not explained by the pharmacologic properties of the drug. An example is the individual with infectious mononucleosis who develops a rash when given ampicillin.
What causes idiosyncratic reaction?
Many idiosyncratic reactions are initiated by reactive drug metabolites, which bind covalently to macromolecules and either cause direct cell damage or trigger an immune response (Guengerich, 2006).
What is idiosyncrasy in pharmacology?
Idiosyncrasy is an abnormal reactivity to a chemical that is peculiar to a given individual. It could be: An abnormally exaggerated response, or an abnormal lack of response. A response unusual because it requires an unusually small or unusually large dose. An extension of the normal physiological drug effect.
What is idiosyncrasy in toxicology?
“Drug idiosyncrasy” refers to untoward reactions to drugs that occur in a small fraction of patients and have no obvious relationship to dose or duration of therapy. The liver is a frequent target for toxicity.
What is paradox reaction?
A paradoxical reaction or paradoxical effect is an effect of a chemical substance, typically a medical drug, that is opposite to what would usually be expected. An example of a paradoxical reaction is pain caused by a pain relief medication.
What medications should you not stop abruptly?
10 Medications That Are Dangerous to Stop Abruptly
- 1) Clonidine (Catapres)
- 3) Venlafaxine ER (Effexor XR)
- 4) Paroxetine (Paxil)
- 5) Benzodiazepines.
- 6) Topiramate (Topamax)
- 7) Gabapentin (Neurontin)
- 9) Opioid pain medications.
- 10) Baclofen (Lioresal)
When an abnormal or unusual reaction to a drug?
An adverse drug reaction (ADR) is an injury caused by taking medication. ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs.
What is a hypersensitivity?
Hypersensitivity reactions (HR) are immune responses that are exaggerated or inappropriate against an antigen or allergen. Coombs and Gell classified hypersensitivity reactions into four forms.
What is the difference between tolerance and Tachyphylaxis?
The term tachyphylaxis is used to describe desensitization that occurs very rapidly, sometimes with the initial dose. The term tolerance is conventionally used to describe a more gradual loss of response to a drug that occurs over days or weeks.
What’s the meaning of Tachyphylaxis?
Tachyphylaxis (Greek ταχύς, tachys, “rapid”, and φύλαξις, phylaxis, “protection”) is a medical term describing an acute, sudden decrease in response to a drug after its administration; i.e. a rapid and short-term onset of drug tolerance. It can occur after an initial dose or after a series of small doses.
Which is an example of an idiosyncratic drug reaction?
“Drug idiosyncrasy” refers to untoward reactions to drugs that occur in a small fraction of patients and have no obvious relationship to dose or duration of therapy. The liver is a frequent target for toxicity. What are some examples of adverse drug events?
What is the meaning of the word idiosyncratic?
Besides, what is an idiosyncratic effect? Noun. idiosyncratic reaction (plural idiosyncratic reactions) (pharmacy, medicine) A reaction to a medication that is unusual and unpredictable, specific to a particular person. Unlike allergy, it can occur on first exposure to the medication; unlike a side effect, it affects only very few individuals.
Is it possible to predict an idiosyncratic reaction?
To be clear, an idiosyncratic reaction is abnormal in nature and is therefore not possible to predict who may develop one, when, or what specific form it will take ahead of time. While the good news is that idiosyncratic reactions aren’t all that common, the bad news is that when they do occur, many tend to be life-threatening in nature.
What does idiosyncratic toxicity mean in pharmacology?
In pharmacology, idiosyncrasy refers to an idiosyncratic reaction, which is an adverse effect to an agent, such as a drug, which does not occur in most patients who’ve used the same agent. In lay terms, when we say someone has a certain idiosyncrasy , we refer to a habit or mannerism that’s peculiar to that person.