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Which is an example of an idiosyncratic reaction?

Which is an example of an idiosyncratic reaction?

Idiosyncratic reactions are unpredictable and not explained by the pharmacologic properties of the drug. An example is the individual with infectious mononucleosis who develops a rash when given ampicillin.

What causes idiosyncratic reaction?

Many idiosyncratic reactions are initiated by reactive drug metabolites, which bind covalently to macromolecules and either cause direct cell damage or trigger an immune response (Guengerich, 2006).

What is idiosyncrasy in pharmacology?

Idiosyncrasy is an abnormal reactivity to a chemical that is peculiar to a given individual. It could be: An abnormally exaggerated response, or an abnormal lack of response. A response unusual because it requires an unusually small or unusually large dose. An extension of the normal physiological drug effect.

What is idiosyncrasy in toxicology?

“Drug idiosyncrasy” refers to untoward reactions to drugs that occur in a small fraction of patients and have no obvious relationship to dose or duration of therapy. The liver is a frequent target for toxicity.

What is paradox reaction?

A paradoxical reaction or paradoxical effect is an effect of a chemical substance, typically a medical drug, that is opposite to what would usually be expected. An example of a paradoxical reaction is pain caused by a pain relief medication.

What medications should you not stop abruptly?

10 Medications That Are Dangerous to Stop Abruptly

  • 1) Clonidine (Catapres)
  • 3) Venlafaxine ER (Effexor XR)
  • 4) Paroxetine (Paxil)
  • 5) Benzodiazepines.
  • 6) Topiramate (Topamax)
  • 7) Gabapentin (Neurontin)
  • 9) Opioid pain medications.
  • 10) Baclofen (Lioresal)

When an abnormal or unusual reaction to a drug?

An adverse drug reaction (ADR) is an injury caused by taking medication. ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs.

What is a hypersensitivity?

Hypersensitivity reactions (HR) are immune responses that are exaggerated or inappropriate against an antigen or allergen. Coombs and Gell classified hypersensitivity reactions into four forms.

What is the difference between tolerance and Tachyphylaxis?

The term tachyphylaxis is used to describe desensitization that occurs very rapidly, sometimes with the initial dose. The term tolerance is conventionally used to describe a more gradual loss of response to a drug that occurs over days or weeks.

What’s the meaning of Tachyphylaxis?

Tachyphylaxis (Greek ταχύς, tachys, “rapid”, and φύλαξις, phylaxis, “protection”) is a medical term describing an acute, sudden decrease in response to a drug after its administration; i.e. a rapid and short-term onset of drug tolerance. It can occur after an initial dose or after a series of small doses.

Which is an example of an idiosyncratic drug reaction?

“Drug idiosyncrasy” refers to untoward reactions to drugs that occur in a small fraction of patients and have no obvious relationship to dose or duration of therapy. The liver is a frequent target for toxicity. What are some examples of adverse drug events?

What is the meaning of the word idiosyncratic?

Besides, what is an idiosyncratic effect? Noun. idiosyncratic reaction (plural idiosyncratic reactions) (pharmacy, medicine) A reaction to a medication that is unusual and unpredictable, specific to a particular person. Unlike allergy, it can occur on first exposure to the medication; unlike a side effect, it affects only very few individuals.

Is it possible to predict an idiosyncratic reaction?

To be clear, an idiosyncratic reaction is abnormal in nature and is therefore not possible to predict who may develop one, when, or what specific form it will take ahead of time. While the good news is that idiosyncratic reactions aren’t all that common, the bad news is that when they do occur, many tend to be life-threatening in nature.

What does idiosyncratic toxicity mean in pharmacology?

In pharmacology, idiosyncrasy refers to an idiosyncratic reaction, which is an adverse effect to an agent, such as a drug, which does not occur in most patients who’ve used the same agent. In lay terms, when we say someone has a certain idiosyncrasy , we refer to a habit or mannerism that’s peculiar to that person.

Which is an example of an idiosyncratic reaction?

Which is an example of an idiosyncratic reaction?

Idiosyncratic reactions are unpredictable and not explained by the pharmacologic properties of the drug. An example is the individual with infectious mononucleosis who develops a rash when given ampicillin.

What is an idiosyncratic drug response?

The term idiosyncratic drug reaction (IDR) has been used in various ways and has no clear definition, but the term is used in this review to designate an adverse reaction that does not occur in most patients treated with a drug and does not involve the therapeutic effect of the drug.

What causes idiosyncratic reaction?

Many idiosyncratic reactions are initiated by reactive drug metabolites, which bind covalently to macromolecules and either cause direct cell damage or trigger an immune response (Guengerich, 2006).

What is idiosyncrasy in medication administration?

ABSTRACT. “Drug idiosyncrasy” refers to untoward reactions to drugs that occur in a small fraction of patients and have no obvious relationship to dose or duration of therapy.

What is toxic effect?

toxic effect in British English noun. an adverse effect of a drug produced by an exaggeration of the effect that produces the therapeutic response.

What medications should you not stop abruptly?

10 Medications That Are Dangerous to Stop Abruptly

  • 1) Clonidine (Catapres)
  • 3) Venlafaxine ER (Effexor XR)
  • 4) Paroxetine (Paxil)
  • 5) Benzodiazepines.
  • 6) Topiramate (Topamax)
  • 7) Gabapentin (Neurontin)
  • 9) Opioid pain medications.
  • 10) Baclofen (Lioresal)

What is an unexpected reaction to a drug the first time a patient takes it?

An adverse reaction is an unexpected negative reaction to a medication or treatment that is used in an approved manner. While sometimes used interchangeably with side effects, the term side effect often refers to effects that are minor or confer less harm.

Is there such a thing as an idiosyncratic drug reaction?

Unsourced material may be challenged and removed. Idiosyncratic drug reactions, also known as type B reactions, are drug reactions that occur rarely and unpredictably amongst the population. This is not to be mistaken with idiopathic, which implies that the cause is not known.

What is the idiosyncratic reaction to neuroleptics?

Neuroleptic malignant syndrome (NMS) is an uncommon but potentially fatal idiosyncratic reaction to neuroleptics and characterized by a distinctive clinical syndrome of mental status change, rigidity, fever, and dysautonomia. The former is caused by the endogenous liver toxicity and idiosyncratic reaction to the drugs.

Who is more likely to have an idiopathic drug reaction?

Patients who have multiple idiopathic effects that are nonspecific are more likely to have anxiety and depression. Idiosyncratic drug reactions appear to not be concentration dependent. A minimal amount of drug will cause an immune response, but it is suspected that at a low enough concentration,…

Which is an idiosyncratic reaction to mercury exposure?

Acrodynia, meaning extremity pain, is an idiosyncratic reaction to mercury exposure seen in childhood. Although this is not definitively established, it is believed that ciliochoroidal effusion caused by indapamide and other sulfonamides represents an idiosyncratic reaction [1, 4].

Which is an example of an idiosyncratic reaction?

Which is an example of an idiosyncratic reaction?

Idiosyncratic reactions are unpredictable and not explained by the pharmacologic properties of the drug. An example is the individual with infectious mononucleosis who develops a rash when given ampicillin.

What are idiosyncratic symptoms?

Idiosyncratic reactions are adverse reactions to foods that occur through unknown mechanisms. As suggested by this definition, idiosyncratic illnesses are poorly understood. In fact, the cause-and-effect relationship implicating the food or food ingredient as the cause of the illness is often quite weak.

What is the idiosyncrasy of a drug?

Abstract. “Drug idiosyncrasy” refers to untoward reactions to drugs that occur in a small fraction of patients and have no obvious relationship to dose or duration of therapy. The liver is a frequent target for toxicity.

What causes idiosyncratic reaction?

Many idiosyncratic reactions are initiated by reactive drug metabolites, which bind covalently to macromolecules and either cause direct cell damage or trigger an immune response (Guengerich, 2006).

What is idiosyncratic toxicity?

Idiosyncratic toxicity can occur when a convergence of risk factors, including drug exposure, tips the risk-benefit balance away from benefit and toward risk.

When an abnormal or unusual reaction to a drug?

Idiosyncratic drug reactions, also known as type B reactions, are drug reactions that occur rarely and unpredictably amongst the population. This is not to be mistaken with idiopathic, which implies that the cause is not known.

What is an idiosyncratic person?

Idio is ancient Greek for “one’s own.” An idiosyncratic person is someone who does things in his own way. And the original meaning of idiot was basically “a regular Joe” — an ordinary person who keeps to himself. Definitions of idiosyncratic. adjective. peculiar to the individual.

What drugs have the worst side effects?

The Top 15 Most Dangerous Drugs

  1. Acetaminophen (Tylenol) Common names for Acetaminophen include Tylenol, Mapap, and Feverall.
  2. Alcohol. Alcohol includes all types of beer, wine, and malt liquor.
  3. Benzodiazepines.
  4. Anticoagulants.
  5. Antidepressants.
  6. Anti-Hypertensives.
  7. Bromocriptine.
  8. Clarithromycin.

What are the side effect of Covid 19?

Throughout the rest of your body:

  • Tiredness.
  • Headache.
  • Muscle pain.
  • Chills.
  • Fever.
  • Nausea.

What is the meaning of the word idiosyncratic?

Besides, what is an idiosyncratic effect? Noun. idiosyncratic reaction (plural idiosyncratic reactions) (pharmacy, medicine) A reaction to a medication that is unusual and unpredictable, specific to a particular person. Unlike allergy, it can occur on first exposure to the medication; unlike a side effect, it affects only very few individuals.

What does idiosyncratic toxicity mean in pharmacology?

In pharmacology, idiosyncrasy refers to an idiosyncratic reaction, which is an adverse effect to an agent, such as a drug, which does not occur in most patients who’ve used the same agent. In lay terms, when we say someone has a certain idiosyncrasy , we refer to a habit or mannerism that’s peculiar to that person.

How does idiosyncratic risk affect the stock market?

Research suggests that idiosyncratic risk accounts for most of the variation in the uncertainty surrounding an individual stock over time, rather than market risk. Idiosyncratic risk can be thought of as the factors that affect an asset such as stock and its underlying company at the microeconomic level.

Which is true about the nature of idiosyncrasy?

pertaining to the nature of idiosyncrasy, or something peculiar to an individual: The best minds are idiosyncratic and unpredictable as they follow the course of scientific discovery.